Vascular Degeneration in Parkinson's Disease
Vascular Degeneration in Parkinson's Disease
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DOI：
10.1111/j.1750-3639.2012.00628.x
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发表时间：
2013-03-01
期刊：
影响因子：
6.4
通讯作者：
Nicholson, Louise F. B.
中科院分区：
文献类型：
--
作者：
Guan, Jian;Pavlovic, Darja;Nicholson, Louise F. B.
血管变性在导致阿尔茨海默病等神经退行性疾病中发挥着重要作用。然而，我们对帕金森病 (PD) 血管成分的了解有限。我们使用免疫组织化学染色和图像分析检查了 PD 和对照病例的人脑组织的血管形态。 PD病例中观察到的退行性形态包括内皮细胞簇的形成，这可能是由毛细血管破碎造成的。与对照病例相比，PD 的毛细血管数量较少（P
Vascular degeneration plays a significant role in contributing to neurodegenerative conditions such as Alzheimer's disease. Our understanding of the vascular components in Parkinson's disease (PD) is however limited. We have examined the vascular morphology of human brain tissue from both PD and the control cases using immunohistochemical staining and image analysis. The degenerative morphology seen in PD cases included the formation of endothelial cell clusters, which may be contributed by the fragmentation of capillaries. When compared to the control cases, the capillaries of PDs were less in number (P