Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States
Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States
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DOI：
10.1086/315616
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发表时间：
2000-06-01
影响因子：
6.4
通讯作者：
Nakazawa, T
中科院分区：
文献类型：
--
作者：
Shirai, M;Hirakawa, H;Nakazawa, T
肺炎衣原体是一种广泛存在的呼吸道病原体，也与动脉粥样硬化有关。测定了日本分离株C. pneumoniae菌株J138。该序列预测了多种编码外膜蛋白（OMP）的基因，包括ompA和porB，另外10个预测的omp基因和27个pmp基因。所有这些都是在美国分离和测序的菌株CWL 029的全基因组序列中检测到的。两株菌外膜蛋白的核苷酸序列同源性为89.6%~ 100%（推导的氨基酸序列同源性为71.1%~ 100%）。基因的整体基因组结构和位置在两种菌株中是相同的。因此，一些独特的外膜蛋白序列可能是必不可少的特定属性，定义了两个C。pneumoniae菌株
Chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. The whole genome sequence was determined for a Japanese isolate, C. pneumoniae strain J138. The sequence predicted a variety of genes encoding outer membrane proteins (OMPs) including ompA and porB, another 10 predicted omp genes, and 27 pmp genes. All were detected in the whole genome sequence of strain CWL029, a strain isolated and sequenced in the United States. A comparative study of the OMPs of the two strains revealed a nucleotide sequence identity of 89.6%-100% (deduced amino acid sequence identity, 71.1%-100%). The overall genomic organization and location of genes are identical in both strains. Thus, a few unique sequences of the OMPs may be essential for specific attributes that define the differential biology of two C. pneumoniae strains.