Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women
Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women
复制标题
DOI：
10.1038/ijo.2008.216
复制
发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Micic, D.
中科院分区：
文献类型：
--
作者：
Sumarac-Dumanovic, M.;Stevanovic, D.;Micic, D.
目的：比较Th 17轴细胞因子浓度（白细胞介素（IL）-17和IL-23）和Th 1轴（IL-12和干扰素（IFN）-γ）在肥胖和消瘦妇女中的作用，并研究它们与促炎脂肪因子瘦素、促炎细胞因子巨噬细胞移动抑制因子（MIF）和肥胖的人体测量和代谢参数的关系。26名肥胖女性（年龄20-52岁，体重指数（BMI）：30-48 kg/m2）和20名健康瘦女性（年龄23-46岁，BMI：18-25 kg/m2）。测量：血浆细胞因子和瘦素水平、BMI、腰围（WC）和胰岛素抵抗指数HOMA结果：肥胖组IL-17、IL-23、MIF和瘦素的血药浓度均高于消瘦组（P值分别为0.002、0.046、0.006和0.002），而IL-12和IFN-γ的血药浓度则无明显差异。IL-17与IL-23之间存在正相关（r（s）= 0.530），处于统计学显著性边界（P = 0.065）。IL-17、IL-23与瘦素、MIF均无相关性，IL-17、IL-23水平与BMI、WC、HOMA指数均无相关性。结论：肥胖妇女IL-23/IL-17轴的激活与腹脂增加、胰岛素抵抗、瘦素、MIF水平无关。
Objective: To compare the concentrations of cytokines belonging to Th17 axis ( interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-gamma) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity.Design: Cross-sectional study.Subjects: Twenty-six obese women (age 20-52 years, body mass index (BMI): 30-48 kg/m(2)) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m(2)).Measurements: Plasma levels of cytokines and leptin, BMI, waist circumference ( WC) and insulin resistance index HOMA (homeostatic model assessment).Results: Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-gamma, were higher in obese compared with lean women (P = 0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r(s) = 0.530), which was at the border of statistical significance (P = 0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index.Conclusion: Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels.