Vitamin E suppresses oxidative stress and glomerulosclerosis in rat remnant kidney
Vitamin E suppresses oxidative stress and glomerulosclerosis in rat remnant kidney
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DOI：
10.1007/s004670050591
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发表时间：
1999-04-01
影响因子：
3
通讯作者：
Chan, JCM
中科院分区：
文献类型：
--
作者：
Hahn, S;Krieg, RJ;Chan, JCM
先前的研究表明，大鼠残肾模型中肾质量的减少诱导转化生长因子β 1（TGF β 1）的过度产生。我们研究了在肾脏质量减少之前给予抗氧化剂维生素E是否可以防止氧化应激，减少TGF β 1的过度产生，并减轻随后的肾小球硬化症。我们的研究结果表明，氧化应激，测量血浆丙二醛的变化，是显着降低了先前的维生素E膳食补充剂。最后，我们的数据表明，膳食维生素E补充剂改善了继发于肾质量减少的TGF β 1的升高，并在本实验的时间过程中抑制了残余肾的肾小球硬化。
Previous studies have shown that reduction of renal mass in the rat remnant kidney model induces overproduction of transforming growth factor beta 1 (TGF beta 1). We investigated whether an antioxidant, vitamin E, administered before the renal mass reduction, could prevent oxidative stress, reduce the overproduction of TGF beta 1, and mitigate against the subsequent glomerulosclerosis. Our results revealed that the oxidative stress, as measured by the change in plasma malondialdehyde, is significantly reduced by prior vitamin E dietary supplementation. Finally, our data show that dietary vitamin E supplementation ameliorates the rise in TGF beta 1 secondary to renal mass reduction and inhibits the glomerular sclerosis of the remnant kidney over the time course of this experiment.