EFFECT OF NITROGLYCERIN AND DIPYRIDAMOLE ON REGIONAL CORONARY RESISTANCE
EFFECT OF NITROGLYCERIN AND DIPYRIDAMOLE ON REGIONAL CORONARY RESISTANCE
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DOI：
10.1161/01.res.22.5.649
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发表时间：
1968-01-01
影响因子：
20.1
通讯作者：
MCGREGOR, M
中科院分区：
文献类型：
--
作者：
FAM, WM;MCGREGOR, M
本文观察了静脉注射硝酸甘油（0.3 ~ 0.6mg）和潘生丁（5 ~ 10 mg）对狗大、小冠状动脉阻力的影响。通过将从主动脉到浅分支的压降除以该血管中的流量来估计大传导血管的电阻变化方向（Rc）。通过将主动脉压与相同流量相关联来估计相同血管中的总阻力（RT）。两种药物对主动脉压的影响在注射后3至7分钟相当。硝酸甘油在此期间引起的减少Re，而潘生丁引起R-p显着减少12分钟，但没有一致的变化Rc。在相同的制剂中，冠状动脉内小剂量的药物几乎不影响主动脉压，引起了相当的阻力变化。这在冠状血管中的流量保持恒定的制剂中也是明显的。因此，这两种药物在冠状血管床上的作用部位不同，这一差异可以解释它们在人类慢性冠状动脉疾病中的对比治疗效果。
Changes caused by intravenous injection of nitroglycerin (0.3 to0.6 mg) and dipyridamole 5 to 10 mg) were studiedon the resistance of large and small coronary arteries of dogs. The direction of change in resistance of large conductive vessels (Rc) was estimated by dividing the pressure drop from aorta to a superficial branch by the flow in thatvessel. The total resistance (RT) in the same vessel was estimated by relating aortic pressure to the same flow. The effects of both drugs on aortic pressure were comparable 3 to 7 minutes after injection. Nitroglycerin during this period caused a reduction in Re, whereas dipyridamole cause a significant reduction in R-p for 12 minutes but no consistent changes in Rc. In the same preparation, small intracoronary doses of the drugs, which hardly affected the aortic pressure, caused comparable changes in resistance. This was also evident in a preparation in which the flow in the coronary vessel was held constant These 2 drugs therefore differ in their site of action on the coronary vascular bed, a difference which may explain their contrasting therapeutic effects in chronic coronary disease in man.