An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?
An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?
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DOI：
10.1158/2159-8290.cd-19-0737
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发表时间：
2019-09
期刊：
影响因子：
28.2
通讯作者：
Melnick, Ari M.
中科院分区：
文献类型：
--
作者：
Li, Meng;Melnick, Ari M.
在本期《Cancer Discovery》中，Zhimin 及其同事开发了一种由 NRasG12D 和 Ezh2−/− 驱动的骨髓增生性肿瘤 (MPN) 小鼠模型，它们至少部分通过基因表达正常表观遗传调控的丧失，协同诱导白血病干细胞 (LSC) 的恶性转化和代谢重编程。此外，他们的研究结果指出 Ezh1 和 BCAA（支链氨基酸）代谢是骨髓肿瘤的生物依赖性和潜在治疗靶点。
In this issue of Cancer Discovery, Zhimin and colleagues developed a mouse model of myeloproliferative neoplasm (MPN) driven by NRasG12D and Ezh2−/− which cooperated to induce malignant transformation and metabolic reprogramming of leukemic stem cells (LSCs) at least in part through loss of normal epigenetic regulation of gene expression. Furthermore, their findings point to Ezh1 and BCAA (branched chain amino acid) metabolism as biological dependencies and potential therapeutic targets in myeloid neoplasms.