Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.
Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.
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DOI：
10.1002/psp4.12230
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Kierzek AM
中科院分区：
文献类型：
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作者：
Maldonado EM;Leoncikas V;Fisher CP;Moore JB;Plant NJ;Kierzek AM
基于生理的药代动力学（PBPK）建模的范围可以通过吸收系统生物学领域的细胞内过程的机制模型来扩展。基因组尺度的代谢网络（GSMNs）代表了人体组织中表达的一整套代谢酶。关键药物代谢酶的基因调控的动态模型是可用的。在这里，我们介绍了gsmn，并对PBPK、gsmn和代谢基因调控的整合进行了综述。我们将演示示例模型。
The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonstrate example models.