The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells
The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells
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DOI：
10.1016/j.jep.2006.03.004
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发表时间：
2006-09-19
影响因子：
5.4
通讯作者：
Chiou, Wen-Fei
中科院分区：
文献类型：
--
作者：
Ko, Han-Chieh;Wei, Bai-Luh;Chiou, Wen-Fei
据报道，感染部位炎症细胞的积累在病毒感染后慢性炎症和多发性硬化症的进展中起着至关重要的作用。本研究以连翘九种乙醇提取物为主要成分。（油棕科）；金银花；（Caprifoliaceae），板蓝花堡。（十字花科）；黄芪（刺科），黄芪（鱼类）知母。（豆科），多叶豆科；豆科；穿心莲；f。)洛克。（五加科），甘草。（豆科）和Ligusticum wallichii Franch。（伞形科）是中国传统上用于治疗可能与炎症和病毒感染相关的疾病的药用植物，研究人员筛选了它们对甲型流感病毒（H1N1）感染的人支气管上皮细胞（A549）分泌RANTES的影响。除金银花、板蓝花、黄芪和红毛草外，在200 μ g/ml浓度下，所有植物对甲型H1N1流感感染的A549支气管上皮细胞分泌RANTES的抑制作用均在50%以上。其中穿心莲抑制RANTES的IC50值为1.2 +/- 0.4 μ g/ml，甘草和连翘抑制RANTES的IC50值为35 ~ 48 μ g/ml。2006爱思唯尔爱尔兰有限公司版权所有。
The accumulation of inflammatory cells in the infective sites has been reported to play a crucial role in the progression of chronic inflammation and multiple sclerosis after viral infection. In the present study, nine ethanol extracts of Forsythia suspensa Vahl. (Oleaceae), Lonicera japonica Thunb. (Caprifoliaceae), Isatis indigotica Fort. (Cruciferae), Strobilanthes cusia (Ness.) O. Kuntze (Acanthaceae), Astragalus membranaceus (Fisch.) Bge. (Leguminosae), Hedysarum polybotrys Hand.-Mazz. (Leguminosae), Andrographis paniculata (Burm. f.) Ness. (Acanthaceae), Glycyrrhiza uralensis Fischer. (Leguminosae) and Ligusticum wallichii Franch. (Umbelliferae), medicinal plants traditionally used in China for treating conditions likely to be associated with inflammation and viral infection, were screened for their effect on RANTES secretion by influenza A virus (H1N1)-infected human bronchial epithelial cells (A549). With exception of Lonicera japonica, Isatis indigotica, Astragalus membranaceus and Hedysarum polybotrys, all plants tested at concentration of 200 mu g/ml possessed more than 50% suppressing effect on RANTES secretion by H1N1 -infected A549 bronchial epithelial cells. Among the plants tested, Andrographis paniculata showed the most promising property to inhibit RANTES secretion with an IC50 Of 1.2 +/- 0.4 mu g/ml while the next two were Glycyrrhiza uralensis and Forsythia suspensa (IC50 ranging from 35 to 48 mu g/ml). (c) 2006 Elsevier Ireland Ltd. All rights reserved.