Total synthesis of (-)-renieramycin G from L-tyrosine
Total synthesis of (-)-renieramycin G from L-tyrosine
复制标题
L-酪氨酸全合成(-)-雷尼尔霉素G
DOI：
10.1016/j.tet.2009.05.025
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发表时间：
2009-07-18
期刊：
影响因子：
2.1
通讯作者：
Liu, Zhan Zhu
中科院分区：
文献类型：
--
作者：
Liao, Xiang Wei;Liu, Wei;Liu, Zhan Zhu
以L-酪氨酸甲酯为手性起始原料，经21步反应合成了（-）-雷尼霉素G，总收率为8.5%。四个手性中心中的两个来自L-酪氨酸甲酯，另外两个分别通过分子间和分子内Pictet-Spengler反应诱导。(C)2009爱思唯尔有限公司版权所有。
(-)-Renieramycin G was synthesized in 21 steps for the longest linear sequences employing L-tyrosine methyl ester as the chiral starting material in 8.5% overall yield. Two of the four chiral centers came from L-tyrosine methyl ester, and the other two were induced through an intermolecular and an intramolecular Pictet-Spengler reaction, respectively. (C) 2009 Elsevier Ltd. All rights reserved.