Overnight deprivation from smoking disrupts amygdala responses to fear
Overnight deprivation from smoking disrupts amygdala responses to fear
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DOI：
10.1002/hbm.21293
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发表时间：
2011-05
影响因子：
4.8
通讯作者：
O. Onur;Alexandra Patin;Y. Mihov;B. Buecher;B. Stoffel‐Wagner;T. Schlaepfer;H. Walter;W. Maier;R. Hurlemann
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文献类型：
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作者：
O. Onur;Alexandra Patin;Y. Mihov;B. Buecher;B. Stoffel‐Wagner;T. Schlaepfer;H. Walter;W. Maier;R. Hurlemann
吸烟是导致残疾和过早死亡的主要但可以避免的原因，是尼古丁成瘾最普遍的形式。尼古丁成瘾神经生物学中的一个新兴主题是杏仁核的完整性。采用功能性磁共振成像技术，比较了28名慢性吸烟者[14名女性，14名男性;年龄，26.3（2.8）岁;开始吸烟的年龄，15.8岁（2.6）年;吸烟年数，9.1（2.1）;每天吸烟17.1支（3.7）;尼古丁依赖评分的Fagerström检验，4.1（1.9）;呼出的一氧化碳水平，17.8（9.5）ppm]和28名年龄和教育程度匹配的不吸烟者[14名女性，14名男性;年龄，26.9（2.4）岁]。受试者在两个不同的场合进行成像，间隔1周：吸烟饱腹感与整夜吸烟剥夺，以随机平衡的顺序。我们的研究结果表明，不吸烟者和饱腹吸烟者的杏仁核对面孔的反应没有差异。然而，一夜之间剥夺吸烟与杏仁核对恐惧的反应显着降低有关，这种效应可能与基底外侧杏仁核有关。我们认为，夜间剥夺吸烟者的异常杏仁核反应可能反映了预先存在的吸烟易感性和/或增加戒烟尝试后吸烟复发的风险。^Brain Mapp，2011.© 2011 Wiley‐利斯公司
Cigarette smoking, a major, yet avoidable, cause of disability and premature death, is the most prevalent form of nicotine addiction. An emerging theme in the neurobiology of nicotine addiction is the integrity of the amygdala. Using functional MRI, amygdala responses during a face perception task were compared between 28 chronic smokers [14 females, 14 males; age, 26.3 (2.8) years; age at onset of smoking, 15.8 (2.6) years; years smoked, 9.1 (2.1); cigarettes per day, 17.1 (3.7); Fagerström test for nicotine dependence score, 4.1 (1.9); exhaled carbon‐monoxide level, 17.8 (9.5) ppm] and 28 age‐ and education‐matched nonsmokers [14 females, 14 males; age, 26.9 (2.4) years]. Subjects underwent imaging on two separate occasions 1 week apart: smoking satiety versus overnight smoking deprivation, in a randomized counterbalanced order. Our results show no difference in amygdala responses to faces between nonsmokers and satiated smokers. However, overnight deprivation from smoking was associated with a significantly lowered amygdala response to fear, an effect that was probabilistically mapped to the basolateral amygdala. We suggest that aberrant amygdala reactivity in overnight‐deprived smokers may reflect a pre‐existing vulnerability to smoking and/or increase the risk of smoking relapse after a cessation attempt. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.