DIESEL EXHAUST EXPOSURE AND SMOKING - A CASE-REFERENT STUDY OF LUNG-CANCER AMONG SWEDISH DOCK WORKERS
DIESEL EXHAUST EXPOSURE AND SMOKING - A CASE-REFERENT STUDY OF LUNG-CANCER AMONG SWEDISH DOCK WORKERS
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DOI：
10.1097/00001648-199305000-00007
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发表时间：
1993-05-01
期刊：
影响因子：
5.4
通讯作者：
WALL, S
中科院分区：
文献类型：
--
作者：
EMMELIN, A;NYSTROM, L;WALL, S
我们研究了50例肺癌病例和154例匹配的参照物，所有码头工人，我们获得了他们的吸烟信息和就业史。我们评估了来自15个港口的年度柴油燃料消耗量信息的暴露。我们在分析中使用了吸烟者/非吸烟者术语和三个暴露变量（机器时间、累积燃料和燃料消耗量高于最低临界点的暴露时间），每个暴露变量分为三类。中等和高暴露组的比值比（OR）始终高于参考值（低），暴露时间变量的风险-反应趋势最明显（OR：低= 1.0;中= 1.6;高= 2.8）。当吸烟和暴露变量同时纳入分析时，中等（OR = 2.7）和高（OR = 6.8）暴露水平的比值比增加，吸烟的比值比也增加。将吸烟者和非吸烟者分开，以低暴露的非吸烟者作为共同的参考类别，非吸烟者的优势比为1.6（中等）和2.9（高），吸烟者的优势比为10.7（中等）和28.9（高）。这些结果表明柴油机废气暴露的独立影响和吸烟和柴油机废气之间的强烈相互作用。
We studied 50 lung cancer cases and 154 matched referents, all dock workers, for whom we obtained smoking information and employment histories. We assessed exposures from information on annual diesel fuel consumption from each of the 15 ports included. We used a smoker/nonsmoker term and three exposure variables (machine time, cumulative fuel, and exposed time with fuel consumption above a minimum cutpoint) in the analyses, with three categories for each exposure variable. Odds ratios (ORs) for medium and high exposure groups are consistently higher than reference (low), with an increasing exposure-response trend that is most marked for the exposed time variable (ORs: low = 1.0; medium = 1.6; high = 2.8). When smoking and that exposure variable are simultaneously included in the analyses, odds ratios for the medium (OR = 2.7) and high (OR = 6.8) levels of exposure increase, as does the odds ratio for smoking. Separating smokers and nonsmokers, with the low exposed nonsmokers as the common reference category, the odds ratios are 1.6 (medium) and 2.9 (high) for the nonsmokers, and 10.7 (medium) and 28.9 (high) for smokers. These results indicate an independent effect of diesel exhaust exposure and a strong interaction between smoking and diesel exhaust.