Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).
Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).
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异源三聚体 G 蛋白信号传导的非受体激活剂（AGS 蛋白）。
DOI：
10.1016/j.semcdb.2006.03.003
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Cismowski,MaryJ
中科院分区：
文献类型：
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作者：
Cismowski,MaryJ
G蛋白偶联受体（GPCR）信号转导代表哺乳动物细胞中最保守和普遍存在的用于将信息穿过质膜传递到细胞内环境的手段之一。异源三聚体G蛋白亚基在转导这些信号中起关键作用，并且影响这些亚基的活化状态和相互作用的细胞内调节剂调节GPCR信号传导的程度和持续时间。其中一类细胞内调节因子，G蛋白信号的非受体激活剂（或AGS蛋白），是这篇综述的主要焦点。AGS蛋白为理解异源三聚体G蛋白在GPCR驱动的和GPCR独立的细胞信号传导途径中的功能提供了基础。
G-protein coupled receptor (GPCR) signaling represents one of the most conserved and ubiquitous means in mammalian cells for transferring information across the plasma membrane to the intracellular environment. Heterotrimeric G-protein subunits play key roles in transducing these signals, and intracellular regulators influencing the activation state and interaction of these subunits regulate the extent and duration of GPCR signaling. One class of intracellular regulator, the non-receptor activators of G-protein signaling (or AGS proteins), are the major focus of this review. AGS proteins provide a basis for understanding the function of heterotrimeric G-proteins in both GPCR-driven and GPCR independent cellular signaling pathways.