Quantitative Analysis of the Association Between Follow-Up Duration and Severity of Limbal Stem Cell Deficiency or Visual Acuity in Aniridia
Quantitative Analysis of the Association Between Follow-Up Duration and Severity of Limbal Stem Cell Deficiency or Visual Acuity in Aniridia
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DOI：
10.1167/iovs.61.6.57
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发表时间：
2020-06-01
影响因子：
4.4
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
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作者：
Komoto, Shimpei;Oie, Yoshinori;Nishida, Kohji
目的.本研究旨在定量分析随访时间与无虹膜患者角膜缘干细胞缺陷（LSCD）严重程度或视力之间的关系。在大坂大学医院共招募了27例无虹膜患者的52只眼。对病历进行回顾性审查，以获得有关LSCD严重程度和矫正远视力（CDVA）的信息。LSCD严重程度基于改良的严重程度分级量表。我们使用有序逻辑回归模型来检查随访时间和LSCD严重程度之间的关联，并使用线性回归模型和广义线性混合模型来检查随访时间和视力之间的关联。平均随访时间为5.2 - 6.3年。末次随访时的平均年龄为40.5 ± 18.9岁。平均CDVA为1.52 +/- 1.09 logMAR。末次随访时，1只检查眼（1.9%）被分类为0期，7只（13.5%）被分类为Ia期，9只（17.3%）被分类为Ib期，5只（9.6%）被分类为Ic期，2只（3.8%）被分类为IIb期，12只（23.1%）被分类为IIc期，11只（21.2%）被分类为III期。5只眼（9.6%）无法分类。随访持续时间与LSCD严重程度之间存在显著相关性（每+1年的比值比，1.41; P < 0.001）。随着随访时间的增加，CDVA显著降低。随访时间每增加1年，平均差异为+0.021 logMAR（95%置信区间[CI] 0.01-0.03; P < 0.001）。我们定量地证明，LSCD的严重程度和视力损害显着进展，随着随访时间的增加。
PURPOSE. This study aimed to quantitatively analyze the association between follow-up duration and the severity of limbal stem cell deficiency (LSCD) or visual acuity in patients with aniridia.METHODS. A total of 52 eyes of 27 patients with aniridia were enrolled at Osaka University Hospital. Medical records were retrospectively reviewed to obtain information on the severity of LSCD and corrected distance visual acuity (CDVA). LSCD severity was based on a modified severity grading scale. We used an ordered logistic regression model to examine the association between follow-up duration and LSCD severity, and a linear regression model with a generalized linear mixed model for the association between follow-up duration and visual acuity.RESULTS. The mean follow-up duration was 5.2 6.3 years. The mean age at the last follow-up visit was 40.5 18.9 years. The mean CDVA was 1.52 +/- 1.09 logMAR. At the last follow-up, 1 examined eye (1.9%) was categorized as stage 0, 7 (13.5%) as Ia, 9 (17.3%) as Ib, 5 (9.6%) as Ic, 2 (3.8%) as IIb, 12 (23.1%) as IIc, and 11 (21.2%) as III. Five eyes (9.6%) were unclassifiable. There was a significant association between follow-up duration and LSCD severity (odds ratio per +1 year, 1.41; P < 0.001). CDVA significantly decreased as follow-up duration increased. Each increase of 1 year in the follow-up duration was associated with a mean difference of +0.021 logMAR (95% confidence interval [CI] 0.01-0.03; P < 0.001).CONCLUSIONS. We quantitatively demonstrate that LSCD severity and visual impairment significantly progress as follow-up duration increases.