Clinical value of CA 15-3 for detection of distant metastases in newly diagnosed breast cancer
Clinical value of CA 15-3 for detection of distant metastases in newly diagnosed breast cancer
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DOI：
10.1684/abc.2017.1257
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发表时间：
2017-07-01
影响因子：
0.5
通讯作者：
Riedinger, Jean-Marc
中科院分区：
文献类型：
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作者：
Gonssaud, Barbara;Goussot, Vincent;Riedinger, Jean-Marc
本研究的目的是探讨CA 15-3检测新诊断乳腺癌远处转移（DM）的临床价值。这项回顾性研究的重点是1998年3月至2013年10月在CGFL（Centre Georges Francois Leclerc）诊断的1，007例局部晚期乳腺癌（n = 561）或转移性乳腺癌（n = 446）患者。这些患者在接受任何治疗前接受CA 15-3测量和扩展评估。确定CA 15-3的临界值，并在抽签中确定的两个独立亚群上进行验证。ROC曲线显示AUC为0.85（p= 0.70; p 50 kU/L），13例发生DM，11例死于癌症。总之，这些事实证实了治疗前CA 15-3对DM存在的独立预测价值，以及该标志物与通过图像评估扩展的互补性。
The aim of the study is to investigate the clinical value of CA 15-3 for detection of distant metastases (DM) in newly diagnosed breast cancer. This retrospective study focuses on a population of 1,007 patients with locally advanced breast cancer (n = 561) or metastatic breast cancer (n = 446) diagnosed at the CGFL (Centre Georges Francois Leclerc) from March 1998 to October 2013. These patients underwent a measurement of CA 15-3 and an assessment of extension before any treatment. The cut-off value of CA 15-3 was determined and verified on two independents subpopulations determined in drawing lots. The ROC curve shows an AUC of 0.85 (p= 0.70; p 50 kU/L, 13 have developed DM and 11 died of cancer. In conclusion, these facts confirm the independently predictive value of CA 15-3 before treatment on the existence of DM and the complementarity of the marker with the assessment of extension by imagery.