Effect of Anti-Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri-Implant Diseases
Effect of Anti-Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri-Implant Diseases
复制标题
DOI：
10.1902/jop.2009.070672
复制
发表时间：
2009-02-01
影响因子：
4.3
通讯作者：
Nociti, Francisco Humberto, Jr.
中科院分区：
文献类型：
--
作者：
Duarte, Poliana Mendes;de Mendonça, Adriana Cutrim;Nociti, Francisco Humberto, Jr.
背景：本研究的目的是从临床和免疫学角度评价机械抗感染疗法对种植体周围粘膜炎和种植体周围炎的治疗效果，并比较未治疗和治疗的种植体周围病变部位的细胞因子水平与健康组的差异。方法：将钛种植体分为以下组：健康组(n=10)=对照组；粘膜炎组(n=10)=使用研磨性碳酸钠气粉和树脂涂层进行机械清创；以及种植体周围炎(n=20)=使用研磨性碳酸钠气粉和树脂涂层进行开放性手术清创。所有组在基线和疾病组治疗后3个月评估可见的斑块堆积、边缘出血、探诊出血、化脓和探诊深度。用双抗体夹心酶联免疫吸附试验检测种植体周腔液中IL-4、-10、-12、肿瘤坏死因子-α(TNF-α)、核因子-kappa B受体激活剂(RANKL)和护骨素(OPG)的含量。结果：3个月后，抗感染治疗后粘膜炎和种植体周围炎的各项临床指标均有明显改善(P
Background: The objectives of this study were to clinically and immunologically assess the effects of mechanical anti-infective therapies for mucositis and peri-implantitis and to compare the levels of cytokines in untreated and treated peri-implant diseased sites to healthy ones.Methods: Titanium dental implants were assigned to one of the following groups: healthy (n = 10) = control; mucositis (n = 10) = mechanical debridement using abrasive sodium carbonate air-powder and resin curets; and peri-implantitis (n = 20) = open surgical debridement using abrasive sodium carbonate air-powder and resin curets. Visible plaque accumulation, marginal bleeding, bleeding on probing, suppuration, and probing depth were assessed at baseline for all groups and at 3 months after therapies for diseased groups. At these times, the total amounts of interleukin (IL)-4, -10, and -12, tumor necrosis factor-alpha (TNF-alpha), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) were measured by enzyme-linked immunosorbent assay.Results: At 3 months, the anti-infective treatments resulted in a significant improvement in all clinical parameters for mucositis and peri-implantitis (P