Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine Applications.
Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine Applications.
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DOI：
10.21926/rpm.2003018
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hocking DC
中科院分区：
文献类型：
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作者：
Norris EG;Dalecki D;Hocking DC
超声是一种新兴的有前途的工具，用于表征和制造工程生物材料。基于超声的技术提供了一个多样化的工具箱，具有在各种治疗环境中进行优化和定制的出色能力，包括用于再生医学应用的改进的基于细胞外基质的材料。非侵入性超声制造工具包括使用声波的热和机械效应来直接和间接地通过生物化学和细胞介质来改变细胞外基质支架的结构和功能。来源于天然细胞外基质组分的材料是设计用于刺激细胞和组织功能以及修复或替换损伤组织的工程生物材料的基本组分。因此，对生物学和声学机制的持续研究，通过该机制，超声可以用于操纵三维水凝胶内的细胞外基质组分，从而具有很大的潜力，能够生产用于临床和研究应用的改进的生物材料。
Ultrasound is emerging as a promising tool for both characterizing and fabricating engineered biomaterials. Ultrasound-based technologies offer a diverse toolbox with outstanding capacity for optimization and customization within a variety of therapeutic contexts, including improved extracellular matrix-based materials for regenerative medicine applications. Non-invasive ultrasound fabrication tools include the use of thermal and mechanical effects of acoustic waves to modify the structure and function of extracellular matrix scaffolds both directly, and indirectly via biochemical and cellular mediators. Materials derived from components of native extracellular matrix are an essential component of engineered biomaterials designed to stimulate cell and tissue functions and repair or replace injured tissues. Thus, continued investigations into biological and acoustic mechanisms by which ultrasound can be used to manipulate extracellular matrix components within three-dimensional hydrogels hold much potential to enable the production of improved biomaterials for clinical and research applications.