Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats
Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats
复制标题
遗传性和实验性高血压大鼠的疼痛敏感性和阿片类药物活性
DOI：
10.1016/0006-8993(80)90800-8
复制
发表时间：
1980
期刊：
影响因子：
2.9
通讯作者：
M. Segal
中科院分区：
文献类型：
--
作者：
N. Zamir;R. Simantov;M. Segal
研究了肾性高血压大鼠和doca盐性高血压大鼠的疼痛敏感性，以及来自同一亲本品系的两株大鼠对doca盐致高血压的敏感性(H)和免疫力(N)。实验中，高血压大鼠、H大鼠和N大鼠对疼痛刺激的敏感性低于相应的对照组，这在热板和爪试验中得到了评估。纳洛酮在实验性和遗传性高血压大鼠中逆转了这种痛觉减退，而在任何类型的大鼠测试中都没有影响血压。用放射受体法测定了实验性和遗传性高血压大鼠脑区和脑垂体的阿片活性。实验表明，高血压大鼠脊髓中的阿片活性水平比对照组高45%。H和N毒株的大鼠在脊髓、下丘脑和垂体均表现出较高水平的阿片活性。这表明大鼠的血压控制系统和疼痛敏感性密切相关。
Pain sensitivity was studied in renal and DOCA-salt hypertensive rats, and in two strains of rats derived from the same parental strain for their sensitivity (H) or immunity (N) to hypertension induced by DOCA-salt treatment.Experimentally hypertensive rats, and H and N rats were less sensitive to painful stimuli than their appropriate controls, as assessed in the hot-plate and paw tests. Naloxone reversed this hypoalgesia in both experimentally and genetically hypertensive rats while it did not affect blood pressure in any rat-type tested.Opioid activity was measured with the radioreceptor assay in several brain regions and pituary gland of both experimentally and genetically hypertensive rats. Experimentally hypertensive rats had a 45% higher level of opioid activity in the spinal cord compared to control. Rats of the H and N strains both exhibited higher levels of opioid activity in the spinal cord, hypothalamus and pituitary.It is suggested that control systems for blood pressure and pain sensitivity are closely associated in the rat.