Infectious complications of cyclophosphamide treatment for vasculitis.
Infectious complications of cyclophosphamide treatment for vasculitis.
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环磷酰胺治疗血管炎的感染性并发症。
DOI：
10.1002/anr.1780320108
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发表时间：
1989
影响因子：
--
通讯作者：
Katz,BP
中科院分区：
文献类型：
--
作者：
Bradley,JD;Brandt,KD;Katz,BP
15例韦格纳肉芽肿病、结节性多动脉炎或孤立性中枢神经系统脉管炎患者根据广泛使用的方案使用环磷酰胺治疗。在201个患者月的环磷酰胺治疗中观察到17例临床感染发作，2例患者死于肺炎。值得注意的是，白细胞减少的发生率、环磷酰胺或皮质类固醇治疗的剂量或持续时间都与感染无关，而感染最常见于60岁以上的男性。与其他形式的血管炎相比，韦格纳肉芽肿病患者感染的风险更大。这些结果表明，这种治疗方案可能不像以前认为的那样安全。
Fifteen patients with Wegener's granulomatosis, polyarteritis nodosa, or isolated angiitis of the central nervous system were treated with cyclophosphamide according to a widely used regimen. Seventeen clinical episodes of infection were observed over 201 patient‐months of cyclophosphamide therapy, and 2 patients died of pneumonia. Notably, neither the incidence of leukopenia nor the dosage or duration of cyclophosphamide or corticosteroid therapy correlated well with infection, which occurred most frequently in men over 60 years of age. Patients with Wegener's granulomatosis appeared to be at greater risk of infection than those with the other forms of vasculitis. These results suggest that this treatment regimen may not be as safe as was previously thought.