Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank
Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank
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DOI：
10.1016/j.joca.2023.05.012
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发表时间：
2023-10-01
影响因子：
7
通讯作者：
Watt, F. E.
中科院分区：
文献类型：
--
作者：
Hollis, B.;Chatzigeorgiou, C.;Watt, F. E.
目的：急性膝关节损伤与创伤后骨性关节炎(PTOA)相关。与特发性骨性关节炎(IOA)相比，对PTOA的全基因组相关性知之甚少。我们的目标是描述英国生物库(UKB)膝关节损伤后膝骨性关节炎的发展及其遗传相关性。设计：临床上有意义的结构性膝关节损伤
Objective: Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about the genome-wide associations of PTOA when compared with idiopathic OA (iOA). Our objective was to describe the development of knee OA after a knee injury and its genetic associations in UK Biobank (UKB). Design: Clinically significant structural knee injuries in those