Early [18F]florbetaben and [11C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer's disease
Early [18F]florbetaben and [11C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer's disease
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DOI：
10.1007/s00259-016-3353-1
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发表时间：
2016-08-01
影响因子：
9.1
通讯作者：
Barthel, Henryk
中科院分区：
文献类型：
--
作者：
Tiepolt, Solveig;Hesse, Swen;Barthel, Henryk
目的[F-18]FDG是痴呆早期和鉴别诊断的常用神经元损伤生物标志物。通常，大脑的血液供应与葡萄糖消耗密切相关。PET图像上A β示踪剂[C-11]PiB的早期摄取主要由脑血流量决定，并与[F-18]FDG摄取高度相关。然而，F-18标记的A β PET示踪剂的摄取数据很少。方法回顾性分析22例MCI或痴呆患者，在常规临床实践中，采用[C-11]PiB（11例）或[F-18]FBB（11例）进行双时间点PET显像。在给予两种示踪剂后1 - 9 min以及分别给予[C-11]PiB和[F-18]FBB后40 - 70 min和90 - 110 min采集图像。患者还接受了[F-18]FDG脑PET成像。PET数据进行了目视和半定量分析。结果早期A β示踪剂摄取与[18 F]FDG PET图像的局部视觉评分显着相关（斯皮尔曼rho = 0.780，P
Purpose [F-18]FDG is a commonly used neuronal injury biomarker for early and differential diagnosis of dementia. Typically, the blood supply to the brain is closely coupled to glucose consumption. Early uptake of the A beta tracer [C-11]PiB on PET images is mainly determined by cerebral blood flow and shows a high correlation with [F-18]FDG uptake. Uptake data for F-18-labelled A beta PET tracers are, however, scarce. We investigated the value of early PET images using the novel A beta tracer [F-18]FBB in the diagnosis of Alzhimers disease (AD).Methods This retrospective analysis included 22 patients with MCI or dementia who underwent dual time-point PET imaging with either [C-11]PiB (11 patients) or [F-18]FBB (11 patients) in routine clinical practice. Images were acquired 1 - 9 min after administration of both tracers and 40 - 70 min and 90 -110 min after administration of [C-11]PiB and [F-18]FBB, respectively. The patients also underwent [F-18]FDG brain PET imaging. PET data were analysed visually and semiquantitatively. Associations between early A beta tracer uptake and dementia as well as brain atrophy were investigated.Results Regional visual scores of early A beta tracer and [18F]FDG PET images were significantly correlated (Spearman's rho = 0.780, P