Hemodynamic Responses of the Sheep Fetus to Vasopressin Infusion
Hemodynamic Responses of the Sheep Fetus to Vasopressin Infusion
复制标题
羊胎儿对加压素输注的血流动力学反应
DOI：
10.1161/01.res.44.3.430
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发表时间：
1979
影响因子：
20.1
通讯作者：
M. Heymann
中科院分区：
文献类型：
--
作者：
H. Iwamoto;A. Rudolph;L. Keil;M. Heymann
本研究在羔羊子宫内长期留置血管内导管，观察静脉输注加压素对胎儿循环的影响。加压素输注剂量为0.91-2.26 mU/min/kg胎儿体重，导致血浆精氨酸加压素水平为6.8-36.4 μU/ml;这些水平与胎儿缺氧期间达到的水平相似。胎儿平均动脉压由对照组的47 ± 1.7上升到56 ± 1.9 mmHg，心率由174 ± 4.1次/分下降到144 ± 4.4次/分。用放射性核素标记微球技术测定了加压素输注前后胎儿心输出量及其分布。合并心室输出量没有显着变化，但流量发生重新分配，心输出量占胃肠道和外周循环的比例显着降低，心输出量占脐胎盘、心肌和脑循环的百分比增加。这种再分布与胎儿动脉Po从22 ℃到24 ℃的显著增加有关。心率、心输出量和心输出量分布到胎儿各器官的变化与胎儿缺氧时相似，提示血管加压素释放可能在胎儿心血管应激反应中起重要作用。cire Res 44：430-436，1979年
The effects of intravenous infusion vasopressin on the circulation the fetus were studied in lambs utero with chronically maintained intravascular catheters. Vasopressin infused doses of 0.91-2.26 mU/min per kg fetal weight resulted in plasma levels arginine vasopressin of 6.8-36.4 /μU/ml; these levels are similar to those achieved during fetal hypoxia. Petal mean arterial blood pressure increased from control levels of 47 ± 1.7 to 56 1.9 nun Hg, and heart rate fell from 174 4.1to 144 ± 4.4 beats/min. Fetal cardiac output and its distribution actual organ blood flows were measured before and during vasopressin infusion by the radionuclide-labeled microsphere technique. Combined ventricular output did not change significantly, but there was a redistribution of flow, with a marked reduction of the proportion cardiac output to gastrointestinal and peripheral circulations and an increase in the percent of cardiac output to umbilical-placental, myocardial, and cerebral circulations. This redistribution was associated with a significant increase in fetal arterial Po» from 22 to 24 torr. Changes in heart rate, cardiac output, and distribution of cardiac output to various fetal organs are similar to those seen during fetal hypoxia and suggest that vasopressin release may play an important role in the fetal cardiovascular response to stress. cire Res 44: 430-436, 1979