Babesiosis Occurrence Among United States Medicare Beneficiaries, Ages 65 and Older, During 2006-2017: Overall and by State and County of Residence
Babesiosis Occurrence Among United States Medicare Beneficiaries, Ages 65 and Older, During 2006-2017: Overall and by State and County of Residence
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DOI：
10.1093/ofid/ofaa608
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发表时间：
2021-02-01
影响因子：
4.2
通讯作者：
Forshee, Richard A.
中科院分区：
文献类型：
--
作者：
Menis, Mikhail;Whitaker, Barbee, I;Forshee, Richard A.
背景人类巴贝斯虫病是一种轻度至重度的寄生虫感染，特别是在老年人和其他高危人群中造成健康问题。该研究的目的是评估2006- 2017年期间美国医疗保险受益人中65岁及以上人群的巴贝斯虫病发生率。我们的回顾性基于索赔的研究使用了医疗保险数据库。使用记录的诊断代码识别巴贝虫病病例。该研究估计的比率（每100000万年）的整体，按年，诊断月，人口统计学，和州和县的居住。在全国范围内，19469名受益人记录了巴贝斯虫病，发病率为每10万人年6例，从2006年的4例到2017年的9例（P < .05）。各州巴贝斯虫病发病率最高的地区如下：马萨诸塞州（62）、罗得岛（61）、康涅狄格州（51）、纽约（30）和新泽西（19）。按县分列的最高比率如下：马萨诸塞州的南图克特（1089）;马萨诸塞州的杜克斯（236）;马萨诸塞州的巴恩斯特布尔（213）;和纽约的达奇斯（205）。从2006年到2017年（P < .05），在多个州，包括以前被认为是非地方病的州，发现了发病率增加。新罕布什尔州、缅因州、佛蒙特州、宾夕法尼亚州和特拉华州的发病率上升了数倍。我们12年的研究表明，巴贝斯虫病的诊断趋势显著增加，在已确立的地方病状态中发病率最高。它还表明巴贝西虫病感染在其他州的扩大，并强调了现实世界证据的效用。
Background. Human babesiosis is a mild-to-severe parasitic infection that poses health concerns especially in older and other at-risk populations. The study objective was to assess babesiosis occurrence among US Medicare beneficiaries, ages 65 and older, during 2006-2017.Methods. Our retrospective claims-based study used Medicare databases. Babesiosis cases were identified using recorded diagnosis codes. The study estimated rates (per 100000 beneficiary-years) overall, by year, diagnosis month, demographics, and state and county of residence.Results. Nationwide, 19469 beneficiaries had babesiosis recorded, at a rate of 6 per 100000 person-years, ranging from 4 in 2006 to 9 in 2017 (P < .05). The highest babesiosis rates by state were in the following: Massachusetts (62), Rhode Island (61), Connecticut (51), New York (30), and New Jersey (19). The highest rates by county were in the following: Nantucket, Massachusetts (1089); Dukes, Massachusetts (236); Barnstable, Massachusetts (213); and Dutchess, New York (205). Increasing rates, from 2006 through 2017 (P < .05), were identified in multiple states, including states previously considered nonendemic. New Hampshire, Maine, Vermont, Pennsylvania, and Delaware saw rates increase by several times.Conclusions. Our 12-year study shows substantially increasing babesiosis diagnosis trends, with highest rates in well established endemic states. It also suggests expansion of babesiosis infections in other states and highlights the utility of real-world evidence.