Stereotactic Photodynamic Therapy Using a Two-Photon AIE Photosensitizer
Stereotactic Photodynamic Therapy Using a Two-Photon AIE Photosensitizer
复制标题
使用双光子 AIE 光敏剂的立体定向光动力疗法
DOI：
10.1002/smll.201905080
复制
发表时间：
2019-11-13
期刊：
影响因子：
13.3
通讯作者：
Zheng, Lei
中科院分区：
文献类型：
--
作者：
He, Xiaojing;Situ, Bo;Zheng, Lei
双光子光动力疗法（TP-PDT）是一种立体定向靶向治疗疾病的有效方法，但目前缺乏理想的光敏剂。本文报道了一种具有聚集诱导发射（AIE）功能的智能PS，即DPASP，用于TP-PDT，具有优异的性能。DPASP具有与线粒体的高亲和性、上级光稳定性、大的双光子吸收截面以及有效的活性氧产生，使其在双光子激发下实现体内外光敏化。此外，它的能力，立体定向消融靶细胞的高精度也被成功地证明。所有这些优点使DPASP成为一种有希望的TP-PDT候选物，用于在治疗各种疾病时准确消融异常组织，对周围区域的损伤最小。
Two-photon photodynamic therapy (TP-PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation-induced emission (AIE) feature, namely DPASP, for TP-PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two-photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two-photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high-precision is also successfully demonstrated. All these merits make DPASP a promising TP-PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.