INTERLEUKIN-1, INTERLEUKIN-4 AND INTERLEUKIN-6 INDUCE THE COLONY FORMATION OF HUMAN BONE-MARROW B-LINEAGE CELLS
INTERLEUKIN-1, INTERLEUKIN-4 AND INTERLEUKIN-6 INDUCE THE COLONY FORMATION OF HUMAN BONE-MARROW B-LINEAGE CELLS
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DOI：
10.1002/eji.1830210526
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发表时间：
1991-05-01
影响因子：
5.4
通讯作者：
PAIGE, CJ
中科院分区：
文献类型：
--
作者：
MCGINNES, K;PAIGE, CJ
An agar-based, B cell colony assay (McGinnes, K. et al., Blood 1990. 76: 896) has been used to study the influence of known cytokines on the growth of B lineage colonies initiated by cells from normal, human bone marrow samples. We demonstrate that a combination of interleukin (IL)1, IL4 and IL6 act directly to promote the generation of plaque-forming colonies. IL6 was shown to act at a late stage of colony formation, which is consistent with its role in the induction of immunoglobulin secretion from mature B cells. In contrast, IL1 and IL4 were required at earlier stages in the formation of colonies containing cells which secrete immunoglobulin.
