An overview of Cdk1-controlled targets and processes.

An overview of Cdk1-controlled targets and processes.
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DOI:
10.1186/1747-1028-5-11
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发表时间:
2010-05-13
期刊:
影响因子:
2.3
通讯作者:
Kolodner RD
Kolodner RD
中科院分区:
生物学3区
文献类型:
--
作者:
Enserink JM;Kolodner RD

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细胞周期蛋白依赖性激酶Cdk 1控制细胞周期,这在模式生物S中得到最好的理解。啤酒。在过去的十年中进行的研究已经显着提高了我们对细胞周期的分子机制的理解。已经确定了大约75个Cdk 1靶点,它们控制着关键的细胞周期事件,如DNA复制和分离、转录程序和细胞形态发生。在这篇综述中,我们讨论了目前已知的Cdk1在芽殖酵母S。并强调Cdk1在几个关键过程中的作用,包括维持基因组稳定性。
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle. Approximately 75 targets of Cdk1 have been identified that control critical cell cycle events, such as DNA replication and segregation, transcriptional programs and cell morphogenesis. In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability.
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