ADJUVANT CHEMOTHERAPY WITH CYCLOPHOSPHAMIDE OR CMF IN PREMENOPAUSAL WOMEN WITH STAGE-II BREAST-CANCER
ADJUVANT CHEMOTHERAPY WITH CYCLOPHOSPHAMIDE OR CMF IN PREMENOPAUSAL WOMEN WITH STAGE-II BREAST-CANCER
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DOI：
10.1007/bf01806239
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发表时间：
1983-01-01
影响因子：
3.8
通讯作者：
ANDERSEN, KW
中科院分区：
文献类型：
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作者：
BRINCKER, H;MOURIDSEN, HT;ANDERSEN, KW
在全乳切除术和部分腋窝淋巴结清扫术后，805名绝经前II期乳腺癌妇女随机接受术后单纯放疗（RT）、RT +环磷酰胺（C）12个月周期或RT +环磷酰胺/甲氨蝶呤/5-氟尿嘧啶（CMF）12个月周期。RT + C和RT + CMF的3年精确无复发生存率显著优于单独RT（分别为p= 0.0009和0.0001）。RT + C和RT + CMF.C之间的无复发生存期无显著差异导致更明显的血液毒性和更高的频率amphorrhoea和脱发比CMF，而CMF导致更明显的恶心和口腔炎比C。在初步结果中，C单独可能是有效的CMF在延长绝经前妇女的无复发生存期II期乳腺癌。
After total mastectomy and partial axillary dissection, 805 premenopausal women with stage II breast cancer were randomized to receive postoperative radiotherapy (RT) alone, RT + cyclophosphamide (C) for 12 monthly cycles, or RT + cyclophosphamide/methotrexate/5-fluorouracil (CMF) for 12 monthly cycles. At 3 years actuarial relapse-free survival for RT + C and RT + CMF was significantly better than for RT alone (p= 0.0009 and 0.0001, respectively). There was no significant difference in relapse-free survival between RT + C and RT + CMF.C resulted in more pronounced haematologic toxicity and a higher frequency of amenorrhoea and of alopecia than CMF, while CMF resulted in more pronounced nausea and stomatitis than C.In the preliminary results, C alone may be as effective as CMF in prolonging relapse-free survival in premenopausal women with stage II breast cancer.