ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3
ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3
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DOI：
10.1016/j.bbrc.2009.05.098
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发表时间：
2009-07-31
影响因子：
3.1
通讯作者：
Boeckers, Tobias M.
中科院分区：
文献类型：
--
作者：
Liebau, Stefan;Proepper, Christian;Boeckers, Tobias M.
突触后密度（PSD）是一种高度特化的结构，位于并置于兴奋性突触的突触前活跃区。它由多种蛋白质组成，包括受体、信号分子、细胞骨架成分和支架蛋白。ProSAP/Shank蛋白是促进PSD内多种功能的大型多结构域蛋白。他们构建了大型支架，作为受体蛋白和肌动蛋白细胞骨架之间直接和/或间接连接的结构基础。在这里，我们描述了ProSAP2/Shank3的一个新的相互作用伙伴，命名为ProSAP相互作用蛋白2 (ProSAPiP2)，它与其他已知蛋白没有任何密切的同源性。它与ProSAP2/Shank3的PDZ结构域结合，在神经元系统中高度表达。ProSAPiP2位于树突和脊柱中，在PSD中富集，并与肌动蛋白相互作用。因此，ProSAPiP2可能参与了PSD分子与细胞骨架之间的连接。(C) 2009爱思唯尔公司版权所有。
The postsynaptic density (PSD) is a highly specialized structure that is located juxtaposed to the presynaptic active zone of excitatory synapses. It is composed of a variety of proteins that include receptors, signaling molecules, cytoskeletal components and scaffolding proteins. ProSAP/Shank proteins are large multidomain proteins that facilitate multiple functions within the PSD. They build large scaffolds that are the structural basis for the direct and/or indirect connection between receptor proteins and the actin based cytoskeleton. Here, we characterize a novel interaction partner of ProSAP2/Shank3, named ProSAP interacting protein 2 (ProSAPiP2) that does not show any close homology to other known proteins. It binds to the PDZ domain of ProSAP2/Shank3 and is highly expressed in the neuronal system. ProSAPiP2 is located in dendrites and spines, is enriched in the PSD and interacts with actin. Therefore ProSAPiP2 could be involved in the linkage between molecules of the PSD and the cytoskeleton. (C) 2009 Elsevier Inc. All rights reserved.