What do we GANE with age?
What do we GANE with age?
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随着年龄的增长，我们会得到什么？
DOI：
10.1017/s0140525x15001892
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Eppinger,Ben
中科院分区：
文献类型：
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作者：
Nassar,MatthewR;Bruckner,Rasmus;Eppinger,Ben
马瑟和同事对唤醒水平如何调节行为提供了令人印象深刻的跨层面解释，并用从受体药理学到认知功能测量的数据来支持这一观点。这里我们考虑两个相关的问题：（1）为什么大脑应该处于不同的唤醒水平？ (2) 与年龄相关的去甲肾上腺素信号变化对认知功能的预测后果是什么？Mather 和同事开发了一个令人印象深刻的理论模型，将觉醒介导的认知变化与去甲肾上腺素蓝斑 (LC) 投射的轴突末端的局部信号动力学联系起来。作者提供了令人信服的证据来证明生物学和认知之间的联系是如何建立的。然而，他们留下了一个关键问题：为什么大脑会经历影响信息处理的唤醒波动？回答这个问题不仅对于理解马瑟及其同事提出的复杂的生物设计很重要，而且对于理解这种设计会产生适应不良的背景也很重要。在这里，我们探讨了为什么问题，并推测健康老龄化可能构成了这样一种适应不良的背景。
Mather and colleagues provide an impressive cross-level account of how arousal levels modulate behavior, and they support it with data ranging from receptor pharmacology to measures of cognitive function. Here we consider two related questions:(1) Why should the brain engage in different arousal levels? and (2) What are the predicted consequences of age-related changes in norepinephrine signaling for cognitive function?Mather and colleagues have developed an impressive theoretical model linking arousal-mediated changes in cognition to the local signaling dynamics at the axon terminals of noradrenergic locus coeruleus (LC) projections. The authors provide compelling evidence for how this link between biology and cognition is made; however, they leave open a key question: Why should the brain undergo fluctuations in arousal that influence information processing? Answering this question is important not only for appreciating the intricate biological design proposed by Mather and colleagues, but also for understanding the contexts in which such a design would be maladaptive. Here we explore the why question and speculate that healthy aging may constitute one such maladaptive context.