Mortality in beagles irradiated during prenatal and postnatal development. II. Contribution of benign and malignant neoplasia
Mortality in beagles irradiated during prenatal and postnatal development. II. Contribution of benign and malignant neoplasia
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DOI：
10.2307/3579982
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发表时间：
1998-09-01
影响因子：
3.4
通讯作者：
Mallinckrodt, CH
中科院分区：
文献类型：
--
作者：
Benjamin, SA;Lee, AC;Mallinckrodt, CH
为了评估发育期间暴露于电离辐射的终生致癌危害，1，680只比格犬接受了全身暴露于Co-60伽马射线或假暴露。8组120只犬，每组在妊娠早期、中期或晚期，交配后8、28或55天或出生后2天接受15.6-17.5或80.8-88.3 cGy的平均剂量。另一组120只犬在70日龄幼龄时接受的平均剂量为82.6 cGy，另一组240只犬在365日龄幼龄时接受的平均剂量为81.2 cGy。对照组360只，假照射组360只。男女代表人数相等。在1，343只允许活过寿命的狗中，肿瘤形成是一种主要疾病，导致40%的狗死亡。在年轻的狗身上发生的良性和恶性肿瘤显著增加（
To evaluate the lifetime carcinogenic hazards of exposure to ionizing radiation during development, 1,680 beagles received whole-body exposures to Co-60 gamma rays or sham exposures. Eight groups of 120 dogs each received mean doses of 15.6-17.5 or 80.8-88.3 cGy in early, mid; or late gestation, at 8, 28 or 55 days postcoitus or at 2 days after birth. Another group of 120 dogs received a mean dose of 82.6 cGy as 70-day-old juveniles and one group of 240 dogs received a mean dose of 81.2 cGy as 365-day-old young adults. Sham irradiations mere given to 360 controls. Sexes were equally represented. In 1,343 dogs allowed to live out their life span, neoplasia was a major disease, contributing to mortality in 40% of the dogs. There was a significant increase in benign and malignant neoplasms occurring in young dogs (