Sex differences in myelin content of white matter tracts in adolescents with depression
Sex differences in myelin content of white matter tracts in adolescents with depression
复制标题
DOI：
10.1038/s41386-021-01078-3
复制
发表时间：
2021-07-02
影响因子：
7.6
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Ho, Tiffany C.;Sisk, Lucinda M.;Gotlib, Ian H.
抑郁症是一种慢性的、使人衰弱的疾病，通常出现在青春期，这是大脑成熟的重要时期。然而，很少有研究探讨了神经可塑性机制，包括髓鞘形成，是如何受到抑郁症的影响。在这里，我们使用多模式MR成像表征髓鞘，索引R1，在白色物质束以前与抑郁症和比较48名青少年终身抑郁症（45与当前抑郁症，3缓解）和35名健康对照R1。与健康对照组相比，钩束和胼胝体终身抑郁的青少年的R1更高（所有β s > 0.42;所有ps < 0.037）。性别显著调节抑郁症与左侧钩束和胼胝体神经束R1之间的关联（所有β s > 0.86;所有ps < 0.02），因此抑郁症女性青少年在这些神经束中的R1显著高于健康女性青少年（所有β s > 0.82;所有ps < 0.0012）。相反，抑郁和非抑郁男性青少年在这些神经束的R1没有差异（所有ps > 0.32）。虽然分数各向异性（FA），一种基于弥散加权MRI的白色组织的常用检查指标，在我们的样本中，左钩椎与终生抑郁呈正相关（β = 0.56; p = 0.016），但我们没有发现FA抑郁的性别特异性影响的证据。我们的研究结果表明，R1是更敏感的抑郁症的性别特异性的影响比FA，特别是在女性青少年。鉴于髓鞘抑制突触形成和降低大脑可塑性的证据，我们的研究结果涉及经验驱动的区域髓鞘形成作为一种机制，在重要的神经成熟期，如青春期抑郁症。
Depression is a chronic and debilitating condition that often emerges during adolescence, a period of significant brain maturation. Few studies, however, have examined how mechanisms of neuroplasticity, including myelination, are affected by adolescent-onset depression. Here, we used multimodal MR imaging to characterize myelin, indexed by R1, in white matter tracts previously associated with depression and compare 48 adolescents with lifetime depression (45 with current depression, 3 remitted) and 35 healthy controls in R1. Compared to healthy controls, R1 was higher in adolescents with lifetime depression in the uncinate fasciculus and corpus callosum genu (all beta s > 0.42; all ps < 0.037). Sex significantly moderated the association between depression and R1 in the left uncinate fasciculus and corpus callosum genu (all beta s > 0.86; all ps < 0.02), such that depressed female adolescents had significantly higher R1 in these tracts than did healthy female adolescents (all beta s > 0.82; all ps < 0.0012). In contrast, depressed and non-depressed male adolescents did not differ in R1 in these tracts (all ps > 0.32). While fractional anisotropy (FA), a commonly examined measure of white matter organization based on diffusion-weighted MRI, in the left uncinate was positively associated with lifetime depression in our sample (beta = 0.56; p = 0.016), we found no evidence of sex-specific effects of depression in FA. Our results suggest that R1 is more sensitive to sex-specific effects of depression than FA, particularly in female adolescents. Given evidence that myelin inhibits synapse formation and reduces brain plasticity, our findings implicate experience-driven regional myelination as a mechanism underlying depression during periods of significant neural maturation such as adolescence.