Treatment strategies in patients with rheumatoid arthritis for whom methotrexate monotherapy has failed: data from the NOR-DMARD register
Treatment strategies in patients with rheumatoid arthritis for whom methotrexate monotherapy has failed: data from the NOR-DMARD register
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DOI：
10.1136/ard.2011.152363
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发表时间：
2011-12-01
影响因子：
27.4
通讯作者：
Kvien, Tore K.
中科院分区：
文献类型：
--
作者：
Lie, Elisabeth;van der Heijde, Desiree;Kvien, Tore K.
目的比较在甲氨蝶呤（MTX）基础上加用合成疾病缓解抗风湿药（sDMARDs）和肿瘤坏死因子α抑制剂（TNFi）治疗对甲氨蝶呤（MTX）应答不足（IR）的类风湿关节炎（RA）患者的疗效。其次，检查接受MTX+TNFi的患者的结局，对于这些患者，MTX+sDMARD组合也失败了。
Objectives To compare the effectiveness of adding synthetic disease-modifying antirheumatic drugs (sDMARDs) versus tumour necrosis factor a inhibitors (TNFi) to methotrexate (MTX) in patients with rheumatoid arthritis (RA) who were MTX inadequate responders (IR). Second, to examine outcomes in patients receiving MTX+TNFi for whom the MTX+sDMARD combination had also failed.Methods Patients with RA (disease duration