Spontaneous activation of human immunodeficiency virus type 1 in an immunotoxin-resistant variant T cell line
Spontaneous activation of human immunodeficiency virus type 1 in an immunotoxin-resistant variant T cell line
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DOI：
10.1089/088922299310052
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发表时间：
1999-10-10
影响因子：
1.5
通讯作者：
Pincus, S
中科院分区：
文献类型：
--
作者：
Fang, H;Pincus, S
我们以前使用免疫毒素来选择HIV-1变异细胞，这些细胞以极低的水平转录HIV，并且不能产生HIV蛋白。对这些变体之一（E9）的进一步观察证明了HIV生产的自发体外活化，活化机制不同于U1和ACH-2，这两种细胞系可以被活化以在体外表达HIV。
We have previously used immunotoxins to select for HIV-1 variant cells that transcribe HIV at extremely low levels and fail to produce HIV proteins. Further observation of one of these variants (E9) demonstrated spontaneous in vitro activation of HIV production, The mechanism of activation is different from that of U1 and ACH-2, two other cell lines that can be activated to express HIV in vitro.