Neurobiology and treatment of compulsive hoarding.
Neurobiology and treatment of compulsive hoarding.
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神经生物学和强迫性囤积症的治疗。
DOI：
10.1017/s1092852900026912
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发表时间：
2008
期刊：
影响因子：
3.3
通讯作者：
Saxena,Sanjaya
中科院分区：
文献类型：
--
作者：
Saxena,Sanjaya
强迫性囤积症是一种常见且经常致残的神经精神疾病。本文综述了强迫性囤积症的现象学、病因学、神经生物学和治疗。强迫性囤积症是一种独立的临床综合症的一部分，包括难以丢弃、急于保存、杂乱、过度获取、优柔寡断、完美主义、拖延症、混乱和逃避。流行病学和分类学研究表明，强迫性囤积是一种独立但相关的强迫症谱系障碍，经常与强迫症（OCD）共病。强迫性囤积症是一种基因离散的、强烈遗传的表型。神经影像学和神经心理学研究表明，强迫性囤积症在神经生物学上不同于强迫症，并涉及前扣带皮层和其他调节决策、注意力和情绪调节的腹侧和内侧前额皮质区域的功能障碍。强迫性囤积的有效治疗包括药物治疗和认知行为治疗。需要更多的研究来确定强迫性囤积症的病因和病理生理学，并开发出更好的治疗方法。
Compulsive hoarding is a common and often disabling neuropsychiatric disorder. This article reviews the phenomenology, etiology, neurobiology, and treatment of compulsive hoarding. Compulsive hoarding is part of a discrete clinical syndrome that includes difficulty discarding, urges to save, clutter, excessive acquisition, indecisiveness, perfectionism, procrastination, disorganization, and avoidance. Epidemiological and taxometric studies indicate that compulsive hoarding is a separate but related obsessive-compulsive spectrum disorder that is frequently comorbid with obsessive-compulsive disorder (OCD). Compulsive hoarding is a genetically discrete, strongly heritable phenotype. Neuroimaging and neuropsychological studies indicate that compulsive hoarding is neurobiologically distinct from OCD and implicate dysfunction of the anterior cingulate cortex and other ventral and medial prefrontal cortical areas that mediate decision-making, attention, and emotional regulation. Effective treatments for compulsive hoarding include pharmacotherapy and cognitive-behavioral therapy. More research will be required to determine the etiology and pathophysiology of compulsive hoarding, and to develop better treatments for this disorder.