Some neurochemical alterations during acute DDT poisoning.
Some neurochemical alterations during acute DDT poisoning.
复制标题
急性 DDT 中毒期间的一些神经化学变化。
DOI：
10.1016/s0041-008x(73)80014-6
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发表时间：
1973
影响因子：
3.8
通讯作者：
George M. Ling
中科院分区：
文献类型：
--
作者：
P. Hrdina;Radhey L. Singhal;David A.V. Peters;George M. Ling
对大鼠给予致死剂量（600 mg/kg）的1，1，1-三氯-2，2-双（对氯苯基）乙烷（p，p′-DDT），可产生典型的神经毒性体征（例如，过度兴奋、震颤、惊厥和高热），并导致脑乙酰胆碱（ACh）、去甲肾上腺素（NE）和5-羟基吲哚乙酸（5-HIAA）的显著变化。皮质和纹状体乙酰胆碱以及脑干NE的量显着减少，注意到5小时后，管理的杀虫剂。纹状体多巴胺（DA）和脑干5-羟色胺（5-HT）含量无明显变化。p，p′ DDT处理后，脑干5-HIAA明显增强。在帕吉林预处理的大鼠中，p，p′-DDT使5-HT升高，其升高幅度大于单胺氧化酶（MAO）抑制剂单独给药的动物。6-氟色氨酸（6-FT）或α-甲基-p-酪氨酸（α-MT）（5-HT或NE合成的抑制剂）可防止DDT引起的体温升高，但不能防止震颤和惊厥。相反，对氯苯丙氨酸（pCPA）的给药阻断了p，p′-DDT的所有神经毒性体征。此外，放线菌酮，而不是放线菌素D，防止了纹状体乙酰胆碱和脑干5-HIAA，以及震颤和体温过高的发生的变化。这些结果表明，脑内5-HT和NE代谢的变化可能是DDT引起的体温过高的原因，而急性致死剂量的杀虫剂后所看到的震颤和惊厥可能与脑内ACh的变化有关。
Administration of a lethal dose (600 mg/kg) of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p′-DDT) to rats produced typical neurotoxic signs (e.g., hyperexcitability, tremors, convulsions and hyperthermia) and resulted in marked changes in brain acetylcholine (ACh), norepinephrine (NE) and 5-hydroxyindoleacetic acid (5-HIAA). Significant decreases in the amounts of cortical and striatal ACh as well as of brainstem NE were noted 5 hr after the administration of the insecticide. No significant alterations were found in striatal dopamine (DA) and brainstem 5-hydroxytryptamine (5-HT). However, brainstem 5-HIAA was significantly enhanced after treatment with p,p′-DDT. In pargyline-pretreated rats, p,p′-DDT produced increases in 5-HT which were greater than those observed in animals given the monoamine oxidase (MAO) inhibitor alone. Treatment with 6-fluorotryptophan (6-FT) or α-methyl-p-tyrosine (α-MT), inhibitors of 5-HT or NE synthesis, respectively, prevented the DDT-induced hyperthermia, but not the tremors and convulsions. In contrast, administration of p-chlorophenylalanine (pCPA) blocked all of the neurotoxic signs of p,p′-DDT. In addition, cycloheximide, but not actinomycin D, prevented the insecticide-induced changes in striatal ACh and brainstem 5-HIAA, as well as the occurrence of tremors and hyperthermia. These results suggest that changes in the metabolism of brain 5-HT and NE may be responsible for the DDT-induced hyperthermia, while the tremors and convulsions seen after an acute lethal dose of this insecticide may be related to changes in brain ACh.