Homocysteine levels in newly admitted schizophrenic patients
Homocysteine levels in newly admitted schizophrenic patients
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DOI：
10.1016/j.jpsychires.2004.01.003
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发表时间：
2004-07-01
影响因子：
4.8
通讯作者：
Levine, J
中科院分区：
文献类型：
--
作者：
Applebaum, J;Shimon, H;Levine, J
我们先前发现住院的年轻男性精神分裂症患者血浆同型半胱氨酸显著升高。确定这一发现是否已经出现在新入院的精神分裂症患者中似乎很重要。研究了184名连续入院的精神分裂症患者和305名来自雇员筛选项目的对照者的血清同型半胱氨酸水平。同型半胱氨酸水平在这群新入院的精神分裂症患者中显著升高，尤其是在年轻男性中。新入院的男性精神分裂症患者同型半胱氨酸水平升高，这不能以医院营养不良为基础来解释。吸烟可能会使同型半胱氨酸升高1-2 mmol /L，但这不足以解释我们的研究结果。(C) 2004 Elsevier Ltd.版权所有。
We previously found a marked elevation of plasma homocysteine in young male schizophrenic patients in hospital. It seemed important to determine if this finding is already present in newly admitted schizophrenic patients. Serum homocysteine levels were studied in 184 consecutively admitted schizophrenic patients and 305 control subjects from an employee screening program. Homocysteine levels were markedly increased in this population of newly admitted schizophrenic patients, especially in young males. Newly admitted male schizophrenic patients have elevated homocysteine levels that cannot be explained on the basis of poor hospital nutrition. Smoking may raise homocysteine by 1-2 muM/L but this is not a large enough effect to explain our findings. (C) 2004 Elsevier Ltd. All rights reserved.