Regio- and Chemoselective Diboration of Allenes with Unsymmetrical Diboron: Formation of Vinyl and Allyl Boronic Acid Derivatives
Regio- and Chemoselective Diboration of Allenes with Unsymmetrical Diboron: Formation of Vinyl and Allyl Boronic Acid Derivatives
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DOI：
10.1021/acscatal.5b00387
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发表时间：
2015-04-01
期刊：
影响因子：
12.9
通讯作者：
Santos, Webster L.
中科院分区：
文献类型：
--
作者：
Guo, Xi;Nelson, Amanda K.;Santos, Webster L.
描述了使用差别保护的二硼的铂催化的 1,1-二取代丙二烯的末端二硼化反应。二硼化以区域选择性和化学选择性的方式发生，以良好至优异的产率和选择性提供乙烯基和烯丙基硼酸酯。证明了双硼基产物向其他官能团的转化以及化学选择性交叉偶联。
A platinum-catalyzed terminal diboration of 1,1-disubstituted allenes using a differentially protected diboron is described. Diboration occurs in a regio- and chemoselective fashion to furnish vinyl and allyl boronates in good to excellent yield and selectivity. Transformation of the bis-boronyl products to other functional groups as well as in chemoselective cross-coupling is demonstrated.