Protein Arginine Methylation and Citrullination in Epigenetic Regulation.
Protein Arginine Methylation and Citrullination in Epigenetic Regulation.
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DOI：
10.1021/acschembio.5b00942
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发表时间：
2016-03-18
影响因子：
4
通讯作者：
Thompson PR
中科院分区：
文献类型：
--
作者：
Fuhrmann J;Thompson PR
精氨酸残基的翻译后修饰代表了基因表达的表观遗传控制的关键机制。组蛋白精氨酸修饰的异常水平与包括癌症在内的几种疾病的发展有关。近年来，在了解单个精氨酸修饰的生理作用及其对染色质功能的影响方面取得了很大进展。本文综述了组蛋白精氨酸修饰酶的结构和功能及其对基因转录的影响。我们将讨论在各种疾病状态下用小分子靶向这些蛋白质的潜力。
The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.