Anaemia increases the risk of dementia in cognitively intact elderly
Anaemia increases the risk of dementia in cognitively intact elderly
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DOI：
10.1016/j.neurobiolaging.2005.02.007
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发表时间：
2006-02-01
影响因子：
4.2
通讯作者：
Fratiglioni, L
中科院分区：
文献类型：
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作者：
Atti, AR;Palmer, K;Fratiglioni, L
尽管横断面研究发现贫血和痴呆症之间存在关联，但纵向研究提供了相互矛盾的结果。我们假设贫血可能会增加由于慢性脑低氧导致的痴呆的风险。使用瑞典斯德哥尔摩的龚肖门项目的社区纵向研究的基线数据，我们对1435名年龄在75-95岁的非痴呆者进行了为期3年的临床跟踪调查，以发现偶发痴呆病例(DSM-III-R标准)。符合WHO贫血标准的受试者，基线血红蛋白浓度：130g/L(男性)和120g/L(女性)，3年后发展为痴呆症的风险比(HR)更高(HR为1.6%，95%CI：1.1-2.4)。在基线认知良好的人(MMSE>；=26n=1139)中，这种关联更强，在调整了可能与贫血和痴呆症相关的条件后仍然显著。如慢性病、炎症标志物和营养状况指标。即使使用不同的贫血定义界值，心率也会增加。因此，贫血被认为是痴呆的一个新的潜在的可改变的危险因素。(C)2005 Elsevier Inc.保留所有权利。
Although cross-sectional Studies found an association between anaemia and dementia, longitudinal studies provided contradictory results. We hypothesize that anaemia might increase the risk of developing dementia because of chronic brain hypo-oxygenation.Using baseline data from a community-based longitudinal study, the Kungsholmen Project, Stockholm, Sweden, we clinically followed 1435 non demented Subjects aged 75-95 years for 3 years to detect incident dementia cases (DSM-III-R criteria).Subjects that fulfilled WHO criteria for anaemia, baseline haemoglobin concentration: 130 g/L (men) and 120 g/L (women), had a higher hazard ratios (HR) of developing dementia 3 years later (HR 1.6 95% Cl: 1.1-2.4). In persons with good baseline cognition (MMSE >= 26 n = 1139), the association was stronger and still significant after adjustments for conditions potentially related to anaemia and dementia. Such as chronic diseases, inflammatory markers, and indicators of nutritional status. The HR was increased even when different haemoglobin Cut offs for anaemia definition were used. Thus, anaemia is suggested to be a new potential modifiable risk factor for dementia. (C) 2005 Elsevier Inc. All rights reserved.