MicroRNAs regulate bone metabolism
MicroRNAs regulate bone metabolism
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DOI：
10.1007/s00774-013-0537-7
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发表时间：
2014-05
影响因子：
3.3
通讯作者：
Xin Zhao;Dan Xu;Yi Li;Jiangyan Zhang;Tingting Liu;Yinli Ji;Jufang Wang;Guangming Zhou;
中科院分区：
文献类型：
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作者：
Xin Zhao;Dan Xu;Yi Li;Jiangyan Zhang;Tingting Liu;Yinli Ji;Jufang Wang;Guangming Zhou;
骨质疏松症是由骨形成和骨吸收之间的不平衡引起的。骨稳态受复杂机制的调节。近年来，发现一类新的调控因子microRNAs（miRNAs）在细胞周期调控、细胞凋亡以及代谢和分化等细胞过程中发挥重要作用。已发表的数据表明，一些miRNA通过调节某些细胞因子和转录因子的表达来调节骨稳态，包括骨形成、骨吸收、骨重塑、骨修复和骨相关疾病。本文就miRNAs在骨形成、骨吸收及骨质疏松症发生发展中的作用机制作一综述。
Osteoporosis is caused by an unbalance between bone formation and bone resorption. Bone homeostasis is regulated by intricate mechanisms. Recently, a novel class of regulatory factors termed microRNAs (miRNAs) has been found to play a crucial role in cell cycle control, apoptosis and other cellular processes including metabolism and differentiation. Published data have shown that some miRNAs regulate bone homeostasis, including bone formation, resorption, remodeling, repair and bone-related disease, by regulating the expression of certain cytokines and transcription factors. This review highlights the current knowledge of miRNAs and their involvement in the regulation of bone formation, bone resorption and the pathways regulating the progression of osteoporosis.