Middle-aged endurance athletes exhibit lower cerebrovascular impedance than sedentary peers.
Middle-aged endurance athletes exhibit lower cerebrovascular impedance than sedentary peers.
复制标题
中年耐力运动员的脑血管阻抗比久坐的同龄人低。
DOI：
10.1152/japplphysiol.00239.2020
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tarumi,Takashi
中科院分区：
文献类型：
--
作者：
Sugawara,Jun;Tomoto,Tsubasa;Repshas,Justin;Zhang,Rong;Tarumi,Takashi
由于血流动力学脉动性升高可能是对大脑的机械应力，因此中枢动脉和脑动脉的阻尼功能至关重要。定期耐力运动训练有利于恢复老年人主动脉和颈动脉的阻尼功能恶化，但其对脑血管阻尼功能的影响仍然未知。为了解决这个问题，我们比较了21名从事耐力训练和比赛>10年的中年运动员（MA，53 ± 4岁）与21名年龄匹配的久坐者（MS，53 ± 5岁）和21名年轻人（YS，29 ± 6岁）的脑血管阻抗，脑压力和流量的频域关系。使用传递函数分析，脑血管阻抗计算从同时记录的颈动脉压力（CAP，通过压平眼压计）和大脑中动脉血流速度（CBFV，通过经颅多普勒）。在0.78- 3.12Hz频率范围内，各组CAP和CBFV脉动变化的相关性均大于0.90。所有受试者在主要源自心脏射血的第一谐波振荡（0.78-1.56 Hz）范围内表现出最高的阻抗模量。MA组在该范围内的阻抗模量显著低于MS组（0.88 ± 0.24 vs. 1.15 ± 0.29 mmHg·s/cm，P= 0.011），与YS组相当（0.92 ± 0.30 mmHg·s/cm）。在中年受试者中，较高的阻抗模量与较低的平均CBFV（r= − 0.776，P < 0.001）和MRI评估的大脑皮质灌注（r= − 0.371，P = 0.015）相关。这些结果表明，中年耐力运动员脑血管阻抗模量显著降低，这与较高的CBFV和大脑皮层灌注量有关。新&值得注意的一次谐波振荡范围内的阻抗模量（0.78-1.56 Hz），反映了静息时的心率，在中年耐力运动员中，比年龄匹配的久坐不动的同龄人低，与年轻人相似。长期耐力训练与中年人脑血管缓冲功能的改善有关。较低的脑血管阻抗模量可能有助于维持中年脑灌注。
Because elevated hemodynamic pulsatility could be mechanical stress against the brain, the dampening function of central and cerebral arteries is crucial. Regular endurance exercise training favorably restores the deteriorated dampening function of the aorta and carotid arteries in older populations, yet its effect on cerebrovascular dampening function remains unknown. To address this question, we compared cerebrovascular impedance, a frequency-domain relationship of the cerebral pressure and flow, in 21 middle-aged masters athletes who have been engaged in endurance training and races for >10 yr (MA, 53 ± 4 yr) with sedentary 21 age-matched (MS, 53 ± 5 yr) and 21 young (YS, 29 ± 6 yr) individuals. Using transfer function analysis, cerebrovascular impedance was computed from the simultaneously recorded carotid artery pressure (CAP, via applanation tonometry) and middle cerebral artery blood flow velocity (CBFV, via transcranial Doppler). In the frequency range of 0.78–3.12 Hz, coherence between pulsatile changes in CAP and CBFV was higher than 0.90 in all groups. All subjects exhibited the highest impedance modulus in the range of the first harmonic oscillations (0.78–1.56 Hz) mainly originating from cardiac ejection. Impedance modulus in this range was significantly lower in the MA than MS groups (0.88 ± 0.24 vs. 1.15 ± 0.29 mmHg·s/cm,P= 0.011) and equivalent to the YS (0.92 ± 0.30 mmHg·s/cm). Among middle-aged subjects, higher impedance modulus was correlated with lower mean CBFV (r= −0.776,P< 0.001) and cerebral cortical perfusion evaluated by MRI (r= −0.371,P= 0.015). These results suggest that middle-aged endurance athletes exhibited the significantly lower modulus of cerebrovascular impedance, which is associated with higher CBFV and cerebral cortical perfusion.NEW & NOTEWORTHYImpedance modulus in the range of first harmonic oscillations (0.78–1.56 Hz), which reflects heart rate at rest, was lower in middle-aged endurance athletes than in age-matched sedentary peers and was similar to young individuals. Prolonged endurance training is associated with the improved cerebrovascular dampening function in middle-aged adults. Lower cerebrovascular impedance modulus may contribute to maintaining brain perfusion in midlife.