An approach to the skeleton of the Securinega alkaloids.: The total synthesis of (±)-securinine
An approach to the skeleton of the Securinega alkaloids.: The total synthesis of (±)-securinine
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DOI：
10.1021/ol0070482
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发表时间：
2001-03-08
期刊：
影响因子：
5.2
通讯作者：
Bordner, J
中科院分区：
文献类型：
--
作者：
Liras, S;Davoren, JE;Bordner, J
[图表]描述了从容易获得的起始原料经九步合成一叶秋碱的简明全合成。合成的关键步骤包括将甲硅烷基氧基呋喃添加到原位生成的亚胺离子和新颖的闭环复分解反应。
[GRAPHICS]The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.