Nanoscale porphyrin assemblies based on charge-transfer strategy with enhanced red-shifted absorption.
Nanoscale porphyrin assemblies based on charge-transfer strategy with enhanced red-shifted absorption.
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DOI：
10.1016/j.jcis.2022.07.088
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发表时间：
2022-07
影响因子：
9.9
通讯作者：
Qihang Wu;Rui Xia;Haifang Wen;Tingting Sun;Zhigang Xie
中科院分区：
文献类型：
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作者：
Qihang Wu;Rui Xia;Haifang Wen;Tingting Sun;Zhigang Xie
电荷转移组件（cta）因其优异的光学性能而成为一类新型的功能材料，在生物医学领域具有广阔的应用前景。卟啉是一种应用广泛的光敏剂，但由于其吸收波长短，限制了其实际应用。为了获得红移吸收的卟啉光治疗剂，通过优化供体-受体的化学计量比，制备了5,10,15,20-四（4-氨基苯基）卟啉（TAPP）和7,7,8,8 -四氰喹啉二甲烷（TCNQ）的电荷转移纳米组装体（TAPP-TCNQ NPs）。所制备的ttap - tcnq NPs在近红外（NIR）区域表现出红移吸收，并且由于电荷转移相互作用而增强了吸光度。其中，TAPP-TCNQ NPs具有光动力和光热治疗能力，在808 nm激光照射下可有效杀灭细菌。这种模块化组装方法为增强光疗剂的应用提供了一种替代策略。
Charge-transfer assemblies (CTAs) represent a new class of functional material due to their excellent optical properties, and show great promise in the biomedical field. Porphyrins are widely used photosensitizers, but the short absorption wavelengths may restrict their practical applications. To obtain porphyrin phototherapeutic agents with red-shifted absorption, charge-transfer nanoscale assemblies (TAPP-TCNQ NPs) of 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) and 7,7,8,8‑tetracyanoquinodimethane (TCNQ) were preparedviaoptimizing the stoichiometric ratios of donor–acceptor. The as-prepared TAPP-TCNQ NPs exhibit red-shifted absorption to the near-infrared (NIR) region and enhanced absorbance because of the charge-transfer interactions. In especial, TAPP-TCNQ NPs possess the capacity of both photodynamic and photothermal therapy, thus effectively killing the bacteria upon 808 nm laser irradiation. This modular assembly method provides an alternative strategy to enhance the application of the phototherapeutic agents.