NONINVASIVE IMAGING OF TC-99M-LABELED LOW-DENSITY-LIPOPROTEIN UPTAKE BY TENDON XANTHOMAS IN HYPERCHOLESTEROLEMIC PATIENTS
NONINVASIVE IMAGING OF TC-99M-LABELED LOW-DENSITY-LIPOPROTEIN UPTAKE BY TENDON XANTHOMAS IN HYPERCHOLESTEROLEMIC PATIENTS
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DOI：
10.1161/01.atv.10.2.256
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
VALLABHAJOSULA, S
中科院分区：
文献类型：
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作者：
GINSBERG, HN;GOLDSMITH, SJ;VALLABHAJOSULA, S
技术标记的低密度脂蛋白（Tc-LDL）似乎有助于描述LDL在正常和血脂异常受试者中的生物分布。我们将99mTc-LDL注射到继发于纯合子家族性高胆固醇血症或谷固醇血症的大腱黄瘤患者体内。在黄瘤中观察到Tc-99m活性的快速积累（4小时），并且这种积累在24小时内增加。在正常受试者或患有杂合性家族性高胆固醇血症且肌腱黄瘤很小的受试者中，Tc-99m活性没有可比较的积累。这些发现支持了先前的活检数据，表明黄瘤内巨噬细胞主动摄取LDL，并提示黄瘤的99mTc-LDL成像可能有助于研究饮食和药物对动脉粥样硬化斑块脂蛋白积累的影响。
Technetium-labeled low density lipoproteins (Tc-LDL) appear to be useful for describing LDL biodistribution in normal and dyslipidemic subjects. We injected 99mTc-LDL into subjects with large tendon xanthomas secondary to homozygous familial hypercholesterolemia or sitosterolemia. Rapid (4 hours) accumulation of Tc-99m activity in xanthomas was observed, and this accumulation increased over a 24-hour period. No comparable accumulations of Tc-99m activity were noted in normal subjects or in a subject with heterozygous familial hypercholesterolemia who had very small tendon xanthomas. These findings support previous biopsy data indicating active uptake of LDL by macrophages within xanthoma and suggest that 99mTc-LDL imaging of xanthomas may be useful in studies of the effects of diet and drugs on the accumulation of lipoproteins by atherosclerotic plaques.