N-FORMYLMETHIONYL PEPTIDES AS CHEMOATTRACTANTS FOR LEUKOCYTES
N-FORMYLMETHIONYL PEPTIDES AS CHEMOATTRACTANTS FOR LEUKOCYTES
复制标题
DOI：
10.1073/pnas.72.3.1059
复制
发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
WAHL, SM
中科院分区：
文献类型：
--
作者：
SCHIFFMANN, E;CORCORAN, BA;WAHL, SM
中性粒细胞等白细胞被N-甲酰甲硫氨酸吸引，但不被甲硫氨酸吸引。含有甲酰甲硫氨酸的二肽和三肽是中性粒细胞和巨噬细胞的强吸引剂，而相应的非酰化化合物则不具有趋化性。甲酰化肽可能与通常由吸引相同动物细胞的细菌产生的不完全表征的趋化物质有关。
Leucocytes such as neutrophils are attracted by N-formylmethionine, but not by methionine. Di- and tripeptides containing formylmethionine are strong attractants for both neutrophils and macrophages, whereas the corresponding nonacylated compounds are not chemotactic. The formylated peptides may be related to an incompletely characterized chemotactic material normally produced by bacteria which attract the same animal cells.