Satellite signaling at synapses.

Satellite signaling at synapses.
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DOI:
10.4161/fly.7133
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发表时间:
2008-09
期刊:
Fly
影响因子:
1.2
通讯作者:
Ganetzky B
Ganetzky B
中科院分区:
生物学4区
文献类型:
--
作者:
O'Connor-Giles KM;Ganetzky B

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Neural function requires effective communication between neurons and their targets at synapses. Thus, proper formation, growth and plasticity of synapses are critical to behavior. A retrograde (muscle to neuron) BMP signal is required to promote synaptic growth, homeostasis and stability at Drosophila neuromuscular junctions (NMJs). We recently demonstrated that this signal constitutes an instructive signal that sculpts synaptic growth in a graded manner and uncovered a presynaptic endocytic mechanism that modulates BMP signaling levels. In the absence of this regulation, excessive BMP signaling results in overgrown NMJs with a proliferation of ectopic boutons.
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