Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.
Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.
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DOI：
10.1039/c2ob27324a
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发表时间：
2013-03
影响因子：
3.2
通讯作者：
Jun Wu;Rong Huang;Tianlu Wang;Xi Zhao;Wanyi Zhang;X. Weng;Tian Tian-Tian;Xiang Zhou
中科院分区：
文献类型：
--
作者：
Jun Wu;Rong Huang;Tianlu Wang;Xi Zhao;Wanyi Zhang;X. Weng;Tian Tian-Tian;Xiang Zhou
两个新的小分子化合物，它们经历氟化物介导的自身重排，产生活性DNA烷化剂氮芥，导致DNA损伤和最终细胞死亡，提供潜在的抗肿瘤前药。
Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.