Prognostic value of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging for patients with prostate cancer.
Prognostic value of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging for patients with prostate cancer.
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DOI：
10.1016/s1095-0397(01)00065-6
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发表时间：
2002-01-01
影响因子：
3.1
通讯作者：
Okada, Kenichiro
中科院分区：
文献类型：
--
作者：
Oyama, Nobuyuki;Akino, Hironobu;Okada, Kenichiro
目的：本研究的目的是探讨使用 2-脱氧-2-[F-18]氟-D-葡萄糖正电子发射断层扫描 (FDG-PET) 测量原发性前列腺癌病灶葡萄糖代谢的预后价值。 方法：对 42 例前列腺癌患者进行 FDG-PET 检查，并计算前列腺标准化摄取值 (SUV)。经过PET检查后，17例患者（RPT组）进行了根治性前列腺切除术，25例患者（ET组）进行了内分泌治疗。采用Kaplan-Meier法绘制无复发生存曲线。结果：在RPT组中，SUV高的患者与SUV低的患者相比预后较差(P=0.033)。在 ET 组中，SUV 高的患者预后可能较差，显着性较低，P = 0.087。结论：FDG-PET 对接受根治性前列腺切除术的前列腺癌患者似乎具有明确的预后价值，对于接受内分泌治疗的患者，需要对更多患者进行研究。
PURPOSE: The purpose of this study was to investigate the prognostic value of measuring glucose metabolism of primary prostate cancer lesions, using 2-Deoxy-2-[F-18]Fluoro-D-Glucose positron emission tomography (FDG-PET).PROCEDURES: Forty-two patients with prostate cancer were investigated with FDG-PET, and standardized uptake value (SUV) of the prostate was calculated. After PET study, radical prostatectomy was performed in 17 patients (RPT group), and endocrine therapy in 25 patients (ET group). Relapse-free survival curves were created by the Kaplan-Meier method.RESULTS: In the RPT group, the patients with high SUV had a poorer prognosis compared to those with low SUV (P = 0.033). In the ET group, the patients with high SUV were likely to have a poorer prognosis with low significance at a level of P = 0.087.CONCLUSIONS: FDG-PET appeared to have a defined prognostic value for patients with prostate cancer undergoing radical prostatectomy, and more patients need to be studied for patients undergoing endocrine therapy.