The chemopreventive and chemotherapeutic potentials of tea polyphenols.
The chemopreventive and chemotherapeutic potentials of tea polyphenols.
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DOI：
10.2174/138920112798868584
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发表时间：
2012-01
影响因子：
2.8
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Thakur VS;Gupta K;Gupta S
茶是世界上消费量第二大的饮料，据报道具有多种健康益处。茶多酚的预防和治疗益处包括增强总体健康和抗肿瘤作用。茶的药理作用通常归因于其中存在的各种儿茶素。在癌细胞系和动物模型中进行的实验表明，茶多酚可以防止氧化应激和免疫力改变引起的细胞损伤。茶多酚改变多种代谢和信号通路，调节增殖、凋亡、血管生成和转移，从而限制癌细胞的克隆扩增。茶多酚已被证明可以重新激活肿瘤抑制因子，阻断癌细胞的无限复制潜力，并与参与基因调控的表观遗传改变的核酸物理结合。绿色茶作为一种潜在的化学预防剂已经产生了显着的兴趣，因为最近的表观遗传数据表明，茶多酚有可能逆转表观遗传修饰，否则可能是致癌的。像绿色茶一样，红茶也可能具有化学预防和化学治疗的潜力;然而，仍然没有足够的证据来做出任何结论性的声明。在这里，我们对茶多酚进行了简要描述，并讨论了有关茶多酚抗癌作用的各种体外和体内研究的结果。详细讨论了各种研究相关的表观遗传变化引起的茶多酚导致预防肿瘤发生或癌症进展。最后对茶多酚在肿瘤防治中的应用范围和发展前景进行了展望。
Tea is the second most consumed beverage in the world reported to have multiple health benefits. Preventive and therapeutic benefits of tea polyphenols include enhanced general well being and anti-neoplastic effects. The pharmacologic action of tea is often attributed to various catechins present therein. Experiments conducted in cancer cell lines and animal models demonstrate that tea polyphenols protect against cellular damage caused by oxidative stress and altered immunity. Tea polyphenols modify various metabolic and signaling pathways in the regulation of proliferation, apoptosis, angiogenesis, and metastasis and therefore restrict clonal expansion of cancer cells. Tea polyphenols have been shown to reactivate tumor suppressors, block the unlimited replicative potential of cancer cells, and physically bind to nucleic acids involved in epigenetic alterations of gene regulation. Remarkable interest in green tea as a potential chemopreventive agent has been generated since recent epigenetic data showed that tea polyphenols have the potential to reverse epigenetic modifications which might otherwise be carcinogenic. Like green tea, black tea may also possess chemopreventive and chemotherapeutic potential; however, there is still not enough evidence available to make any conclusive statements. Here we present a brief description of tea polyphenols and discuss the findings of various in vitro and in vivo studies of the anticancer effects of tea polyphenols. Detailed discussion of various studies related to epigenetic changes caused by tea polyphenols leading to prevention of oncogenesis or cancer progression is included. Finally, we discuss on the scope and development of tea polyphenols in cancer prevention and therapy.