Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography
Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography
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DOI：
10.1364/boe.6.005021
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
van Soest, Gijs
中科院分区：
文献类型：
--
作者：
Wang, Tianshi;Pfeiffer, Tom;van Soest, Gijs
心脏运动伪影、不均匀旋转失真和欠采样影响图像质量和血管内光学相干断层扫描（IV-OCT）的诊断效果。在这项研究中，我们展示了IV-OCT的这些局限性是如何通过使用我们称为“心跳OCT”的成像系统来解决的，该成像系统结合了快速傅立叶域模式锁定激光，快速回拉和微电机驱动导管，旨在在不到一个心脏周期的时间内检查冠状血管。我们获得了猪心脏两条冠状动脉的体内数据集，使用心跳OCT，工作在2.88 MHz a线速率，4000帧/秒和100毫米/秒的回拉速度，并使用商业系统。体内实验结果表明，与传统的IV-OCT数据不同，Heartbeat OCT提供了忠实呈现、无运动伪影、充分采样的血管壁结构。我们介绍心跳OCT系统的全部技术细节，并讨论该技术的临床翻译所需的步骤。(C) 2015美国光学学会
Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called "Heartbeat OCT", combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology. (C) 2015 Optical Society of America