Can resistance against quorum-sensing interference be selected?
Can resistance against quorum-sensing interference be selected?
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DOI：
10.1038/ismej.2015.84
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发表时间：
2016-01-01
期刊：
影响因子：
11
通讯作者：
Wood, Thomas K.
中科院分区：
文献类型：
--
作者：
Garcia-Contreras, Rodolfo;Maeda, Toshinari;Wood, Thomas K.
群体感应（QS）干扰是一种对抗细菌感染的新疗法，与传统的抗生素治疗不同，它专注于减少病原体（毒力）造成的损害，而不是专注于抑制它们的生长。考虑到这一理想，预测这种方法将不受细菌群体的耐药性影响或至少不太容易产生耐药性。然而，最近，在实验室和临床菌株中发现了对特征良好的群体淬灭剂（QQ）的抗性机制，表明对这些化合物的抗性的增加是可能的。然而，有人认为，即使存在针对QS干扰的耐药机制，这一事实也不能保证耐药会扩散。在目前的工作中，我们讨论了最近的见解来自最新的实验来解决这个问题。此外，我们还解释了环境条件（如宿主免疫系统产生的压力）如何影响抗性的选择，并最终导致在临床环境中选择QS干扰抗性细菌。
Quorum-sensing (QS) interference is a novel therapy to fight bacterial infections that, unlike conventional antibiotic treatments, is focused on reducing the damage caused by pathogens (virulence) rather than focused on inhibiting their growth. Given this ideal, it was predicted that this approach will be impervious to or at least much less prone to resistance in bacterial populations. However, recently, resistance mechanisms against well-characterized quorum quenchers (QQs) have been found in the laboratory as well as in clinical strains, demonstrating that the rise of resistance against these kinds of compounds is possible. Nevertheless, it has been argued that even if resistance mechanisms against QS interference exist, this fact does not guarantee that resistance will spread. In the present work, we discuss recent insights derived from the latest experiments to address this question. In addition, we explain how environmental conditions like the stress produced by the host immune system may influence the selection of resistance and eventually lead to the selection of QS interference-resistant bacteria in a clinical setting.